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Therapeutics Says Phase 2 Major Depressive Disorder Study Fails to Meet Primary Efficacy Endpoint","url":"https://stock-news.laohu8.com/highlight/detail?id=2667695720","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667695720?lang=en_us&edition=fundamental","pubTime":"2026-09-15 04:52","pubTimestamp":1789419160,"startTime":"0","endTime":"0","summary":"Contineum Therapeutics  said late Monday the phase 2 MOONLIGHT-1 trial of JNJ-5120/PIPE-307 for the treatment of major depressive disorder did not meet its primary efficacy endpoint.JNJ-5120/PIPE-307 is being developed by Johnson & Johnson  under a global license and development agreement, the company noted.The study evaluated improvement from baseline in the Montgomery-Asberg Depression Rating Scale total score at Day 5 compared with placebo, the company said, adding that the treatment was well tolerated and showed no new safety signals.Johnson & Johnson is continuing to review the trial data, including prespecified exploratory endpoints, to determine next steps for the program, according to a 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PLC Stock Outperforms Competitors on Strong Trading Day","url":"https://stock-news.laohu8.com/highlight/detail?id=2667457695","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667457695?lang=en_us&edition=fundamental","pubTime":"2026-09-15 04:38","pubTimestamp":1789418280,"startTime":"0","endTime":"0","summary":"DJ Medtronic PLC Stock Outperforms Competitors On Strong Trading DayThis article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Medtronic PLC  advanced 3.12% to $93.80 Monday, on what proved to be an all-around poor trading session for the stock market, with the S&P 500 Index  falling 0.48% to 7,619.98 and Dow Jones Industrial Average  falling 0.29% to 52,421.20.The stock's rise snapped a four-day losing streak.Medtronic PLC closed 11.78% below its 52-week high of $106.33, which the company reached on November 26th.The stock outperformed some of its competitors Monday, as Johnson & Johnson  rose 0.28% to $266.32, Danaher Corp.  rose 1.55% to $203.25, and Abbott Laboratories  rose 1.12% to $103.09.Trading volume  eclipsed its 50-day average volume of 7.5 M.Data source: Dow Jones Market Data, FactSet. Data compiled September 14, 2026.","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU0053666078.USD","TRUH","TMED","IE00B42XCP33.USD","LU0289961442.SGD","IE000BZT7R73.USD","IE0002141913.USD","LU2456880835.USD","BMED","BK4568","BK4532","LU1935042991.SGD","LU2111349929.HKD","LU0203347892.USD","LU0069063385.USD","FMED","IYH","LU1721429402.USD","IHI","JNJ","LU1989764664.SGD","GDOC","LU2089984988.USD","IHE","XLV","FHLC","IXJ","LU2265009873.SGD","IE0000B7K699.USD","MEDX","ABT","LU0109391861.USD","IE00BGHQF631.EUR","LU0106261372.USD","LU0472753341.HKD","PJP","LU0496365809.HKD","FTXH","DHR","SG9999001440.SGD","VHT","MDT","LU2028103732.USD","LU2468319806.SGD","RXL","JDOC","LU0320765489.SGD","LU0234572021.USD","LU2023250504.SGD","LU0098860793.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2667695187","title":"Contineum Therapeutics Shares Fall After Drug Trial Missed Primary Endpoint","url":"https://stock-news.laohu8.com/highlight/detail?id=2667695187","media":"Dow Jones","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2667695187?lang=en_us&edition=fundamental","pubTime":"2026-09-15 04:36","pubTimestamp":1789418160,"startTime":"0","endTime":"0","summary":"Shares of Contineum Therapeutics were trading lower after-hours Monday, following news a Phase 2 trial of an treatment for depression failed to meet its primary efficacy endpoint.Contineum said JNJ-5120/PIPE-307 is being developed by Johnson & Johnson under a global license and development agreement. The Phase 2 Moonlight-1 trial didn't meet its primary efficacy endpoint, although the treatment was well-tolerated with no new safety signals, the company added.Analyses of the data are ongoing, Contineum said.After the bell, shares of Contineum were trading 8.2% lower, at $13.59.  The stock ended the day's regular session flat, at 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