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Ionis Pharmaceuticals

46.64

-0.6100-1.29%

Volume:575.95K

Turnover:27.01M

Market Cap:7.75B

PE:-13.40

High:47.59

Open:47.20

Low:46.58

Close:47.25

52wk High:86.74

52wk Low:46.58

Shares:166.18M

Float Shares:161.92M

Volume Ratio:1.37

T/O Rate:0.36%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-3.4800

EPS(LYR):-2.3812

ROE:-105.50%

ROA:-12.42%

PB:17.63

PE(LYR):-19.59

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Overview Company News Filings

Movement Alert｜Ionis Pharmaceuticals Falls 6.29% in Regular Trading, Continued Pressure from Consecutive Heart Disease Drug Trial Failures

Ionis Pharmaceuticals Price Target Cut to $80.00/Share from $89.00 by Guggenheim

Ionis Pharmaceuticals price target lowered to $80 from $89 at Guggenheim

Guggenheim Reaffirms Their Buy Rating on Ionis Pharmaceuticals (IONS)

BofA Adjusts Price Target on Ionis Pharmaceuticals to $91 From $93

MT Newswires Live

Bank of America Securities Keeps Their Buy Rating on Ionis Pharmaceuticals (IONS)

U.S. Stocks on the MOVE-Best Buy, Peloton, Apple

Ionis Pharmaceuticals price target lowered to $84 from $87 at Raymond James

Royalty Pharma Falls After Novartis' Cholesterol Drug Fails in Study

U.S. Stocks on the MOVE-Sigma Lithium, Shake Shack, Novartis

Movement Alert｜Ionis Pharmaceuticals Falls 7.76% in Regular Trading, Partner Novartis Lp(a) Drug Fails Phase 3 Trial

Ionis Pharmaceuticals price target lowered to $104 from $110 at Morgan Stanley

Ionis Pharmaceuticals, Inc. : TD Cowen Cuts Target Price to $84 from $94

THOMSON REUTERS

Canaccord Genuity Sticks to Its Buy Rating for Ionis Pharmaceuticals (IONS)

Ionis Pharmaceuticals Price Target Cut to $100.00/Share from $115.00 by HC Wainwright & Co.

Analysts Offer Insights on Healthcare Companies: Dyne Therapeutics (DYN), NewAmsterdam Pharma Company (NAMS) and Ionis Pharmaceuticals (IONS)

Movement Alert｜Ionis Pharmaceuticals Falls 12.19% in Pre-Market Trading, Partner Novartis Lp(a) Drug Pelacarsen Fails Phase 3 Cardiovascular Outcomes Trial

Ionis Pharmaceuticals price target lowered to $56 from $69 at Goldman Sachs

Ionis Pharma Shares Down 13.1% Premarket After Co's Heart Drug Fails Late-Stage Trial

THOMSON REUTERS

Ionis Pharma Tumbles After Heart Drug Fails Late-Stage Trial

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Na...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/canaccord-genuity-sticks-to-its-buy-rating-for-ionis-pharmaceuticals-ions-blurbs-news-2?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/canaccord-genuity-sticks-to-its-buy-rating-for-ionis-pharmaceuticals-ions-blurbs-news-2?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665275393","title":"Ionis Pharmaceuticals Price Target Cut to $100.00/Share from $115.00 by HC Wainwright & 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NewAmsterdam Pharma Company (NAMS) and Ionis Pharmaceuticals (IONS)","url":"https://stock-news.laohu8.com/highlight/detail?id=2665232230","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665232230?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:50","pubTimestamp":1788864614,"startTime":"0","endTime":"0","summary":"There’s a lot to be optimistic about in the Healthcare sector as 3 analysts just weighed in on Dyne Therapeutics (DYN), NewAmsterdam Pharma Company...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-dyne-therapeutics-dyn-newamsterdam-pharma-company-nams-and-ionis-pharmaceuticals-ions-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-offer-insights-on-healthcare-companies-dyne-therapeutics-dyn-newamsterdam-pharma-company-nams-and-ionis-pharmaceuticals-ions-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4505","IONS","LU0128526141.USD","BK4139","BK4588","BK4137","DYN","LU0029874061.USD","XBI","HCSG","BK4581","XLV","BK4585","NAMS","LABU"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1165504833","title":"Movement Alert｜Ionis Pharmaceuticals Falls 12.19% in Pre-Market Trading, Partner Novartis Lp(a) Drug Pelacarsen Fails Phase 3 Cardiovascular Outcomes Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=1165504833","media":"Market Focus","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1165504833?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:45","pubTimestamp":1788864311,"startTime":"0","endTime":"0","summary":"On September 8, Ionis Pharmaceuticals fell 12.19% in pre-market trading, trading at $50.95/share, with turnover of $4.99 million.On the news front, partner Novartis announced on September 4 that...","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":"Ionis Tumbles as Novartis 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The pelacar...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-56-from-69-at-goldman-sachs-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-56-from-69-at-goldman-sachs-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665732457","title":"Ionis Pharma Shares Down 13.1% Premarket After Co's Heart Drug Fails Late-Stage Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2665732457","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665732457?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:32","pubTimestamp":1788863565,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260908:nL4N4500QY:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665839324","title":"Ionis Pharma Tumbles After Heart Drug Fails Late-Stage Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2665839324","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665839324?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:22","pubTimestamp":1788862967,"startTime":"0","endTime":"0","summary":"BUZZ-Ionis Pharma tumbles after heart drug fails late-stage trial** Ionis Pharmaceuticals'IONS.Oshares fall 12.7% to $50.70 premarket** NovartisNOVN.Sand Ionis said late Friday their experimental drug pelacarsendid not cutthe risk of major heart attacks and strokes in patients with a genetic risk factor in a late-stage trial** The drug successfully lowered a dangerous genetic cholesterol, Lp, but it did not improve overall heart health outcomes** The trial failure was negative for biopharma sector perception because lowering Lp \"did not reduce cardiovascular events in the overall population\", say analysts at Leerink Partners**Amgen'sAMGN.Oand Eli Lilly'sLLY.Ndrugs \"lower Lp more than pelacarsen\" and could now facegreater scrutiny- brokerage** Amgen shares slip 5% to $415.01 before the bell** As of last close, IONS down 26.6% YTD","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260908:nL4N4500PU:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["04332","IE00B4R5TH58.HKD","LU1571399168.USD","LU0058720904.USD","LU0109394709.USD","IE00BFTCPJ56.SGD","LU0889565916.HKD","IE00BJJMRZ35.SGD","LU0320765992.SGD","BK4581","LU0122379950.USD","IE00BJT1NW94.SGD","AMGN","IBBQ","LU0289739699.SGD","BK4139","IE00B2B36J28.USD","SG9999001440.SGD","BBH","PJP","IBB","TBXU","IE0009355771.USD","LU1061106388.HKD","BK4533","LU2242646821.SGD","LU2112291526.USD","IE0002141913.USD","PBE","LU1983299246.USD","BK4588","BK4534","LU0868494617.USD","BK4566","IONS","LU1057294990.SGD","BIB","BK4599","LU1023059063.AUD","BK4585","LU2089984988.USD","LU2468319806.SGD","LU2242652126.USD"],"isVideo":false,"video":null,"gpt_icon":0}],"pageSize":20,"totalPage":10,"pageCount":1,"totalSize":200,"code":"91000000","status":"200"}]}}